Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation

Natural Germacrane Sesquiterpenes Inhibit Osteoclast Formation, Bone Resorption, RANKL-Induced NF-κB Activation, and IκBα Degradation

Osteolytic bone diseases are commonly presented with enhanced osteoclast formation and bone resorption. Sesquiterpene lactone natural compounds have been found to possess anti-inflammatory and immune-modulation effects. Here, we identified three germacrane sesquiterpenes using computer-based virtua...

Full description

Bibliographic Details
Main Authors: Shengnan Qin, Estabelle Ang, Libing Dai, Xiaohong Yang, Dongping Ye, Honghui Chen, Lin Zhou, Mingli Yang, Dian Teguh, Renxiang Tan, Jun Xu, Jennifer Tickner, Nathan J. Pavlos, Jiake Xu
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:International Journal of Molecular Sciences
Subjects:
germacrane sesquiterpenes
osteoclastogenesis
bone resorption
RANKL
NF-κB
IκBα
Online Access:http://www.mdpi.com/1422-0067/16/11/25972

Internet

http://www.mdpi.com/1422-0067/16/11/25972

Similar Items