Naïve B cells reduce fungal dissemination in Cryptococcus neoformans infected Rag1−/− mice

IgM and B-1 cell deficient mice exhibit early C. neoformans dissemination from lungs to brain, but a definitive role for B cells in conferring resistance to C. neoformans dissemination has not been established. To address this question, we developed an intranasal (i.n.) C. neoformans infection model...

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Bibliographic Details
Main Authors: Chad Dufaud, Johanna Rivera, Soma Rohatgi, Liise-anne Pirofski
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
IgM
Online Access:http://dx.doi.org/10.1080/21505594.2017.1370529