Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

Blockade of the IL-1R1/TLR4 pathway mediates disease-modification therapeutic effects in a model of acquired epilepsy

We recently discovered that forebrain activation of the IL-1 receptor/Toll-like receptor (IL-1R1/TLR4) innate immunity signal plays a pivotal role in neuronal hyperexcitability underlying seizures in rodents. Since this pathway is activated in neurons and glia in human epileptogenic foci, it represe...

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Bibliographic Details
Main Authors: Valentina Iori, Anand M. Iyer, Teresa Ravizza, Luca Beltrame, Lara Paracchini, Sergio Marchini, Milica Cerovic, Cameron Hill, Mariella Ferrari, Massimo Zucchetti, Monica Molteni, Carlo Rossetti, Riccardo Brambilla, H. Steve White, Maurizio D'Incalci, Eleonora Aronica, Annamaria Vezzani
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:Neurobiology of Disease
Subjects:
Neuroinflammation
Epilepsy
Seizures
Disease-modification
Hyperexcitability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116302881

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http://www.sciencedirect.com/science/article/pii/S0969996116302881

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