In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

In vivo microscopy reveals macrophage polarization locally promotes coherent microtubule dynamics in migrating cancer cells

The regulation of microtubule (MT) dynamics in cancer cells within the tumor microenvironment is less understood. Here, the authors develop an imaging platform to examine MT dynamics in live xenograft models and show that pro-tumor macrophages modulate MT coherence and alignment to promote cancer ce...

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Bibliographic Details
Main Authors: Gaurav Luthria, Ran Li, Stephanie Wang, Mark Prytyskach, Rainer H. Kohler, Douglas A. Lauffenburger, Timothy J. Mitchison, Ralph Weissleder, Miles A. Miller
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17147-y

Internet

https://doi.org/10.1038/s41467-020-17147-y

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