IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLβ3_D4 domain, and peptides located within these constructs in children with cerebral malaria

IgG acquisition against PfEMP1 PF11_0521 domain cassette DC13, DBLβ3_D4 domain, and peptides located within these constructs in children with cerebral malaria

Abstract The Plasmodium falciparum erythrocyte-membrane-protein-1 (PF3D7_1150400/PF11_0521) contains both domain cassette DC13 and DBLβ3 domain binding to EPCR and ICAM-1 receptors, respectively. This type of PfEMP1 proteins with dual binding specificity mediate specific interactions with brain micr...

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Bibliographic Details
Main Authors: Badaut Cyril, Pimnitah Visitdesotrakul, Aurélie Chabry, Pascal Bigey, Bernard Tornyigah, Jocelyne Roman, Jules Alao Maroufou, Annick Amoussou, Blaise Serge Ayivi, Gratien Sagbo, Nicaise Tuikue Ndam, Andrew V. Oleinikov, Rachida Tahar
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-82444-5

Internet

https://doi.org/10.1038/s41598-021-82444-5

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