BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis

BMP ligands act as retrograde signalling molecules to regulate presynaptic development, and regulation of BMP receptors by endocytosis may be an important component of this signalling pathway. Here, the authors show that Abi-mediated macropinocytosis of BMP receptors in Drosophila larva and contribu...

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Bibliographic Details
Main Authors: Najin Kim, Sungdae Kim, Minyeop Nahm, Danielle Kopke, Joohyung Kim, Eunsang Cho, Min-Jung Lee, Mihye Lee, Seung Hyun Kim, Kendal Broadie, Seungbok Lee
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08533-2