The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism

The glycoprotein uromodulin (UMOD) is the most abundant protein in human urine and forms filamentous homopolymers that encapsulate and aggregate uropathogens, promoting pathogen clearance by urine excretion. Despite its critical role in the innate immune response against urinary tract infections, th...

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Bibliographic Details
Main Authors: Jessica J Stanisich, Dawid S Zyla, Pavel Afanasyev, Jingwei Xu, Anne Kipp, Eric Olinger, Olivier Devuyst, Martin Pilhofer, Daniel Boehringer, Rudi Glockshuber
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
cryo-EM
uromodulin
zona pellucida module
glycoprotein
immunoglobulin-like fold
Online Access:https://elifesciences.org/articles/60265

Internet

https://elifesciences.org/articles/60265

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