PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling

PIEZO1 Ion Channel Mediates Ionizing Radiation-Induced Pulmonary Endothelial Cell Ferroptosis via Ca2+/Calpain/VE-Cadherin Signaling

Pulmonary endothelial cell dysfunction plays an important role in ionizing radiation (IR)-induced lung injury. Whether pulmonary endothelial cell ferroptosis occurs after IR and what are the underlying mechanisms remain elusive. Here, we demonstrate that 15-Gy IR induced ferroptosis characterized by...

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Bibliographic Details
Main Authors: Xue-Wei Guo, Hao Zhang, Jia-Qi Huang, Si-Nian Wang, Yan Lu, Bo Cheng, Su-He Dong, Ying-Ying Wang, Feng-Sheng Li, Yong-Wang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Molecular Biosciences
Subjects:
ferroptosis
Piezo1
calpain
VE-cadherin
ionizing radiation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.725274/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.725274/full

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