Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons

Neurotrophic Factors NGF, GDNF and NTN Selectively Modulate HSV1 and HSV2 Lytic Infection and Reactivation in Primary Adult Sensory and Autonomic Neurons

Herpes simplex viruses (HSV1 and HSV2) establish latency in peripheral ganglia after ocular or genital infection, and can reactivate to produce different patterns and frequencies of recurrent disease. Previous studies showed that nerve growth factor (NGF) maintains HSV1 latency in embryonic sympathe...

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Bibliographic Details
Main Authors: Andy A. Yanez, Telvin Harrell, Heather J. Sriranganathan, Angela M. Ives, Andrea S. Bertke
Format: Article
Language:English
Published: MDPI AG 2017-02-01
Series:Pathogens
Subjects:
herpes simplex virus
HSV1
HSV2
primary neurons
neurotrophic factors
latency
reactivation
Online Access:http://www.mdpi.com/2076-0817/6/1/5

Internet

http://www.mdpi.com/2076-0817/6/1/5

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