Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype

Histone variant MacroH2A1 is downregulated in prostate cancer and influences malignant cell phenotype

Abstract Background Prostate cancer (PCa), a major cause of cancer-related morbidity and mortality worldwide and mostly asymptomatic at earliest stages, is characterized by disruption of genetic and epigenetic balance. A better understanding of how those mechanisms orchestrate disease might improve...

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Bibliographic Details
Main Authors: Tânia Soraia Vieira-Silva, Sara Monteiro-Reis, Daniela Barros-Silva, João Ramalho-Carvalho, Inês Graça, Isa Carneiro, Ana Teresa Martins, Jorge Oliveira, Luis Antunes, Sarah Hurtado-Bagès, Marcus Buschbeck, Rui Henrique, Carmen Jerónimo
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Cancer Cell International
Subjects:
Prostate cancer
Histone variants
MacroH2A1 isoforms
Splicing regulators
Tumor suppressor
Online Access:http://link.springer.com/article/10.1186/s12935-019-0835-9

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http://link.springer.com/article/10.1186/s12935-019-0835-9

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