Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways

Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways

Abstract Background Pirfenidone (PFD) is effective for pulmonary fibrosis (PF), but its action mechanism has not been fully explained. This study explored the signaling pathways involved in anti-fibrosis role of PFD, thus laying a foundation for clinical application. Methods Pulmonary fibrosis mice...

Full description

Bibliographic Details
Main Authors: Qun Lv, Jianjun Wang, Changqing Xu, Xuqing Huang, Zhaoyang Ruan, Yifan Dai
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Medicine
Subjects:
Pirfenidone
Pulmonary fibrosis
Bleomycin
TGF-β1
Signaling pathway
Online Access:http://link.springer.com/article/10.1186/s10020-020-00173-3

Internet

http://link.springer.com/article/10.1186/s10020-020-00173-3

Similar Items