Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction

Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction

Here, we evaluate the mechanisms underlying the neurodevelopmental deficits in Drosophila and mouse models of lysosomal storage diseases (LSDs). We find that lysosomes promote the growth of neuromuscular junctions (NMJs) via Rag GTPases and mechanistic target of rapamycin complex 1 (MTORC1). However...

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Bibliographic Details
Main Authors: Ching-On Wong, Michela Palmieri, Jiaxing Li, Dmitry Akhmedov, Yufang Chao, Geoffrey T. Broadhead, Michael X. Zhu, Rebecca Berdeaux, Catherine A. Collins, Marco Sardiello, Kartik Venkatachalam
Format: Article
Language:English
Published: Elsevier 2015-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715009328

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http://www.sciencedirect.com/science/article/pii/S2211124715009328

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