The Role of the AggR Regulon in the Virulence of the Shiga Toxin-Producing Enteroaggregative Escherichia coli Epidemic O104:H4 Strain in Mice

The Role of the AggR Regulon in the Virulence of the Shiga Toxin-Producing Enteroaggregative Escherichia coli Epidemic O104:H4 Strain in Mice

An O104:H4 Shiga toxin (Stx)-producing enteroaggregative Escherichia coli (EAEC) strain caused a large outbreak of bloody diarrhea and the hemolytic uremic syndrome in 2011. We previously developed an ampicillin (Amp)-treated C57BL/6 mouse model to measure morbidity (weight loss) and mortality of mi...

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Bibliographic Details
Main Authors: Nadia Boisen, Angela R. Melton-Celsa, Anne-Marie Hansen, Tonia Zangari, Mark A. Smith, Lisa M. Russo, Flemming Scheutz, Alison D. O’Brien, James P. Nataro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Microbiology
Subjects:
enteroaggregative Escherichia coli
O104:H4
Shiga toxin
diarrhea
mouse model
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01824/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01824/full

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