Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein

Ablating Tau Reduces Hyperexcitability and Moderates Electroencephalographic Slowing in Transgenic Mice Expressing A53T Human α-Synuclein

Abnormal intraneuronal accumulation of the presynaptic protein α-synuclein (α-syn) is implicated in the etiology of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD). Recent work revealed that mice expressing human α-syn with the alanine-53-threonine (A53T) mutation ha...

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Bibliographic Details
Main Authors: Samuel T. Peters, Allyssa Fahrenkopf, Jessica M. Choquette, Scott C. Vermilyea, Michael K. Lee, Keith Vossel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Neurology
Subjects:
tau
α-synuclein
dementia with Lewy bodies
Parkinson's disease
hyperexcitability
EEG
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2020.00563/full

Internet

https://www.frontiersin.org/article/10.3389/fneur.2020.00563/full

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