Nuclear Progestin Receptor (Pgr) Knockouts in Zebrafish Demonstrate Role for Pgr in Ovulation But Not in Rapid Nongenomic Steroid Mediated Meiosis Resumption

Nuclear Progestin Receptor (Pgr) Knockouts in Zebrafish Demonstrate Role for Pgr in Ovulation But Not in Rapid Nongenomic Steroid Mediated Meiosis Resumption

Progestins, progesterone derivatives, are the most critical signaling steroid for initiating final oocyte maturation (FOM) and ovulation, in order to advance fully-grown immature oocytes to become fertilizable eggs in basal vertebrates. It is well-established that progestin induces FOM via an elusiv...

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Bibliographic Details
Main Authors: Yong eZhu, Dongteng eLiu, Zoe Carena Shaner, Shixi eChen, Wanshu eHong, Edmund J Stellwag
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Endocrinology
Subjects:
Ovulation
Zebrafish
final oocyte maturation
knockout
PGR
gene editing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00037/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2015.00037/full

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