Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance.

Mice deficient in the respiratory chain gene Cox6a2 are protected against high-fat diet-induced obesity and insulin resistance.

Oxidative phosphorylation in mitochondria is responsible for 90% of ATP synthesis in most cells. This essential housekeeping function is mediated by nuclear and mitochondrial genes encoding subunits of complex I to V of the respiratory chain. Although complex IV is the best studied of these complexe...

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Main Authors: Roel Quintens, Sarvjeet Singh, Katleen Lemaire, Katrien De Bock, Mikaela Granvik, Anica Schraenen, Irene Olga Cornelia Maria Vroegrijk, Veronica Costa, Pieter Van Noten, Dennis Lambrechts, Stefan Lehnert, Leentje Van Lommel, Lieven Thorrez, Geoffroy De Faudeur, Johannes Anthonius Romijn, John Michael Shelton, Luca Scorrano, Henri Roger Lijnen, Peter Jacobus Voshol, Peter Carmeliet, Pradeep Puthenveetil Abraham Mammen, Frans Schuit
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3584060?pdf=render

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http://europepmc.org/articles/PMC3584060?pdf=render

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