Abnormal kinetochore-generated pulling forces from expressing a N-terminally modified Hec1.

BACKGROUND: Highly Expressed in Cancer protein 1 (Hec1) is a constituent of the Ndc80 complex, a kinetochore component that has been shown to have a fundamental role in stable kinetochore-microtubule attachment, chromosome alignment and spindle checkpoint activation at mitosis. HEC1 RNA is found up-...

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Bibliographic Details
Main Authors: Marta Mattiuzzo, Giulia Vargiu, Pierangela Totta, Mario Fiore, Claudio Ciferri, Andrea Musacchio, Francesca Degrassi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3030568?pdf=render