Costimulatory blockade of the CD28 / CD80-86 / CTLA-4 balance in transplantation: impact on memory T cells?

Costimulatory blockade of the CD28 / CD80-86 / CTLA-4 balance in transplantation: impact on memory T cells?

CD28 and CTLA-4 are prototypal co-stimulatory and co-inhibitory cell surface signaling molecules interacting with CD80/86, known to be critical for immune response initiation and regulation, respectively. Initial bench-to-beside translation, two decades ago, resulted in the development of CTLA4-Ig,...

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Bibliographic Details
Main Authors: Simon eVille, Nicolas ePoirier, Gilles eBlancho, Bernard eVanhove
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-08-01
Series:Frontiers in Immunology
Subjects:
Transplantation Immunology
CTLA-4
CD28
costimulation blockade
effector T cells
memory T cells
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00411/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00411/full

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