Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity.

Extensive activation, tissue trafficking, turnover and functional impairment of NK cells in COVID-19 patients at disease onset associates with subsequent disease severity.

The SARS-CoV-2 infection causes severe respiratory involvement (COVID-19) in 5-20% of patients through initial immune derangement, followed by intense cytokine production and vascular leakage. Evidence of immune involvement point to the participation of T, B, and NK cells in the lack of control of v...

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Main Authors: Federica Bozzano, Chiara Dentone, Carola Perrone, Antonio Di Biagio, Daniela Fenoglio, Alessia Parodi, Malgorzata Mikulska, Bianca Bruzzone, Daniele Roberto Giacobbe, Antonio Vena, Lucia Taramasso, Laura Nicolini, Nicolò Patroniti, Paolo Pelosi, Angelo Gratarola, Raffaele De Palma, Gilberto Filaci, Matteo Bassetti, Andrea De Maria, GECOVID study group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009448

Internet

https://doi.org/10.1371/journal.ppat.1009448

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