Small-molecule modulation of the p75 neurotrophin receptor inhibits a wide range of tau molecular pathologies and their sequelae in P301S tauopathy mice

Abstract In tauopathies, phosphorylation, acetylation, cleavage and other modifications of tau drive intracellular generation of diverse forms of toxic tau aggregates and associated seeding activity, which have been implicated in subsequent synaptic failure and neurodegeneration. Suppression of this...

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Bibliographic Details
Main Authors: Tao Yang, Harry Liu, Kevin C. Tran, Albert Leng, Stephen M. Massa, Frank M. Longo
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Acta Neuropathologica Communications
Online Access:http://link.springer.com/article/10.1186/s40478-020-01034-0