Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL, which are developmentally targeted to the intesti...

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Bibliographic Details
Main Authors: Alejandro J Brenes, Maud Vandereyken, Olivia J James, Harriet Watt, Jens Hukelmann, Laura Spinelli, Dina Dikovskaya, Angus I Lamond, Mahima Swamy
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-09-01
Series:eLife
Subjects:
T lymphocytes
intestinal immunity
proteomics
immunometabolism
Online Access:https://elifesciences.org/articles/70055

Internet

https://elifesciences.org/articles/70055

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