Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates

Widespread Evolution of Molecular Resistance to Snake Venom α-Neurotoxins in Vertebrates

Venomous snakes are important subjects of study in evolution, ecology, and biomedicine. Many venomous snakes have alpha-neurotoxins (α-neurotoxins) in their venom. These toxins bind the alpha-1 nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction, causing paralysis and asphyxia. Se...

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Bibliographic Details
Main Authors: Muzaffar A. Khan, Daniel Dashevsky, Harald Kerkkamp, Dušan Kordiš, Merijn A. G. de Bakker, Roel Wouters, Jory van Thiel, Bianca op den Brouw, Freek Vonk, R. Manjunatha Kini, Jawad Nazir, Bryan G. Fry, Michael K. Richardson
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Toxins
Subjects:
evolutionary arms race
Elapidae
venom
resistance
nicotinic acetylcholine receptor (nAChR)
CHRNA1
Online Access:https://www.mdpi.com/2072-6651/12/10/638

Internet

https://www.mdpi.com/2072-6651/12/10/638

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