AβPP processing results in greater toxicity per amount of Aβ1-42 than individually expressed and secreted Aβ1-42 in Drosophila melanogaster

The aggregation of the amyloid-β (Aβ) peptide into fibrillar deposits has long been considered the key neuropathological hallmark of Alzheimer's disease (AD). Aβ peptides are generated from proteolytic processing of the transmembrane Aβ precursor protein (AβPP) via sequential proteolysis throug...

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Bibliographic Details
Main Authors: Liza Bergkvist, Linnea Sandin, Katarina Kågedal, Ann-Christin Brorsson
Format: Article
Language:English
Published: The Company of Biologists 2016-08-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/5/8/1030