EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

EphB2-dependent signaling promotes neuronal excitotoxicity and inflammation in the acute phase of ischemic stroke

Abstract Local cerebral hypoperfusion causes ischemic stroke while driving multiple cell-specific responses including inflammation, glutamate-induced neurotoxicity mediated via NMDAR, edema formation and angiogenesis. Despite the relevance of these pathophysiological mechanisms for disease progressi...

Full description

Bibliographic Details
Main Authors: Anne-Sophie Ernst, Laura-Inés Böhler, Anna M. Hagenston, Angelika Hoffmann, Sabine Heiland, Carsten Sticht, Martin Bendszus, Markus Hecker, Hilmar Bading, Hugo H. Marti, Thomas Korff, Reiner Kunze
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Acta Neuropathologica Communications
Subjects:
EphB2
Ephrin-B2
Excitotoxicity
Inflammation
Ischemic stroke
NMDA
Online Access:http://link.springer.com/article/10.1186/s40478-019-0669-7

Internet

http://link.springer.com/article/10.1186/s40478-019-0669-7

Similar Items