Caspase-11 activation in response to bacterial secretion systems that access the host cytosol.

Caspase-11 activation in response to bacterial secretion systems that access the host cytosol.

Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a critical role in inflammatory responses. The inflammasome activates caspase-1 to process and secrete IL-1β. However, the mechanisms governin...

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Bibliographic Details
Main Authors: Cierra N Casson, Alan M Copenhaver, Erin E Zwack, Hieu T Nguyen, Till Strowig, Bahar Javdan, William P Bradley, Thomas C Fung, Richard A Flavell, Igor E Brodsky, Sunny Shin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3675167?pdf=render

Internet

http://europepmc.org/articles/PMC3675167?pdf=render

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