PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting

PARP inhibitors: review of mechanisms of action and BRCA1/2 mutation targeting

Poly(ADP-ribose) polymerases have shown true promise in early clinical studies due to reported activity in BRCA-associated cancers. PARP inhibitors may represent a potentially important new class of chemotherapeutic agents directed at targeting cancers with defective DNA-damage repair. In order to w...

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Bibliographic Details
Main Authors: Karolina N. Dziadkowiec, Emilia Gąsiorowska, Ewa Nowak-Markwitz, Anna Jankowska
Format: Article
Language:English
Published: Termedia Publishing House 2017-02-01
Series:Menopause Review
Subjects:
PARP
BRCA
mutation
olaparib
ovarian cancer
poly(ADP-ribose) polymerases
DNA
PARP1
PARP2
Online Access:https://www.termedia.pl/PARP-inhibitors-review-of-mechanisms-of-action-and-BRCA1-2-mutation-targeting,4,29355,1,1.html

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https://www.termedia.pl/PARP-inhibitors-review-of-mechanisms-of-action-and-BRCA1-2-mutation-targeting,4,29355,1,1.html

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