Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion[S]

Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion[S]

Caspase-1 is known to activate the proinflammatory cytokines IL-1β and IL-18. Additionally, it can cleave other substrates, including proteins involved in metabolism. Recently, we showed that caspase-1 deficiency in mice strongly reduces high-fat diet-induced weight gain, at least partly caused by a...

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Bibliographic Details
Main Authors: Janna A. van Diepen, Rinke Stienstra, Irene O. C.M. Vroegrijk, Sjoerd A.A. van den Berg, Daniela Salvatori, Guido J. Hooiveld, Sander Kersten, Cees J. Tack, Mihai G. Netea, Johannes W.A. Smit, Leo A.B. Joosten, Louis M. Havekes, Ko Willems van Dijk, Patrick C.N. Rensen
Format: Article
Language:English
Published: Elsevier 2013-02-01
Series:Journal of Lipid Research
Subjects:
caspase-1
chylomicron
intestine
lipid absorption
liver
triglyceride metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520428093

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http://www.sciencedirect.com/science/article/pii/S0022227520428093

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