Sinisan Protects Primary Hippocampal Neurons Against Corticosterone by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway

Sinisan Protects Primary Hippocampal Neurons Against Corticosterone by Inhibiting Autophagy via the PI3K/Akt/mTOR Pathway

Objective: Corticosterone causes significant neurotoxicity in primary hippocampal neurons which is associated with depression. Dysfunctional autophagy is implicated in cognitive impairment and depressive-like behavior. The traditional Chinese medicine Sinisan (SNS) is highly effective in clinical tr...

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Bibliographic Details
Main Authors: Mingjia Zhang, Yi Zhang, Haitao Sun, Hui Ni, Jialing Sun, Xuemei Yang, Weicong Chen, Wenting Zhao, Xiaodan Zhong, Chunyu He, Haiqing Ao, Songqi He
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Psychiatry
Subjects:
sinisan
primary hippocampal neurons
corticosterone
autophagy
depression
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627056/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2021.627056/full

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