HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation

HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation

Summary: 5-Hydroxymethylcytosine (5hmC) binding, ES-cell-specific (HMCES) crosslinks to apurinic or apyrimidinic (AP, abasic) sites in single-strand DNA (ssDNA). To determine whether HMCES responds to the ssDNA abasic site in cells, we exploited the activity of apolipoprotein B mRNA-editing enzyme c...

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Bibliographic Details
Main Authors: Kavi P.M. Mehta, Courtney A. Lovejoy, Runxiang Zhao, Darren R. Heintzman, David Cortez
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
replication stress
DNA damage
DNA repair
abasic site
APOBEC
HMCES
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720306756

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http://www.sciencedirect.com/science/article/pii/S2211124720306756

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