In vivo biodistribution analysis of transmission competent and defective RNA virus-based episomal vector

Abstract RNA virus-based episomal vector (REVec) is an emerging viral vector system that mediates long-term stable gene expression in variety of cell types in vitro. However, little is known about its tissue tropism and persistence of gene expression in vivo. Here, to evaluate the feasibility of REV...

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Bibliographic Details
Main Authors: Yumiko Komatsu, Chiaki Tanaka, Ryo Komorizono, Keizo Tomonaga
Format: Article
Language:English
Published: Nature Publishing Group 2020-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-62630-7