Whole-genome mutational burden analysis of three pluripotency induction methods
It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic...
Main Authors: | , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-02-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms10536 |
id |
doaj-6e8a5319f7e748139e1e8df30b2b96e0 |
---|---|
record_format |
Article |
spelling |
doaj-6e8a5319f7e748139e1e8df30b2b96e02021-05-11T10:56:53ZengNature Publishing GroupNature Communications2041-17232016-02-01711810.1038/ncomms10536Whole-genome mutational burden analysis of three pluripotency induction methodsKunal Bhutani0Kristopher L. Nazor1Roy Williams2Ha Tran3Heng Dai4Željko Džakula5Edward H. Cho6Andy W. C. Pang7Mahendra Rao8Han Cao9Nicholas J. Schork10Jeanne F. Loring11Department of Molecular and Experimental Medicine, Scripps Translational Science Institute and The Scripps Research InstituteDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineBioNano GenomicsBioNano GenomicsBioNano GenomicsBioNano GenomicsThe National Institutes of HealthBioNano GenomicsDepartment of Molecular and Experimental Medicine, Scripps Translational Science Institute and The Scripps Research InstituteDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineIt is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.https://doi.org/10.1038/ncomms10536 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring |
spellingShingle |
Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring Whole-genome mutational burden analysis of three pluripotency induction methods Nature Communications |
author_facet |
Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring |
author_sort |
Kunal Bhutani |
title |
Whole-genome mutational burden analysis of three pluripotency induction methods |
title_short |
Whole-genome mutational burden analysis of three pluripotency induction methods |
title_full |
Whole-genome mutational burden analysis of three pluripotency induction methods |
title_fullStr |
Whole-genome mutational burden analysis of three pluripotency induction methods |
title_full_unstemmed |
Whole-genome mutational burden analysis of three pluripotency induction methods |
title_sort |
whole-genome mutational burden analysis of three pluripotency induction methods |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2016-02-01 |
description |
It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential. |
url |
https://doi.org/10.1038/ncomms10536 |
work_keys_str_mv |
AT kunalbhutani wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT kristopherlnazor wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT roywilliams wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT hatran wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT hengdai wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT zeljkodzakula wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT edwardhcho wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT andywcpang wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT mahendrarao wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT hancao wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT nicholasjschork wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods AT jeannefloring wholegenomemutationalburdenanalysisofthreepluripotencyinductionmethods |
_version_ |
1721447293458055168 |