Whole-genome mutational burden analysis of three pluripotency induction methods

It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic...

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Main Authors:	Kunal Bhutani, Kristopher L. Nazor, Roy Williams, Ha Tran, Heng Dai, Željko Džakula, Edward H. Cho, Andy W. C. Pang, Mahendra Rao, Han Cao, Nicholas J. Schork, Jeanne F. Loring
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms10536

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spelling	doaj-6e8a5319f7e748139e1e8df30b2b96e02021-05-11T10:56:53ZengNature Publishing GroupNature Communications2041-17232016-02-01711810.1038/ncomms10536Whole-genome mutational burden analysis of three pluripotency induction methodsKunal Bhutani0Kristopher L. Nazor1Roy Williams2Ha Tran3Heng Dai4Željko Džakula5Edward H. Cho6Andy W. C. Pang7Mahendra Rao8Han Cao9Nicholas J. Schork10Jeanne F. Loring11Department of Molecular and Experimental Medicine, Scripps Translational Science Institute and The Scripps Research InstituteDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineBioNano GenomicsBioNano GenomicsBioNano GenomicsBioNano GenomicsThe National Institutes of HealthBioNano GenomicsDepartment of Molecular and Experimental Medicine, Scripps Translational Science Institute and The Scripps Research InstituteDepartment of Chemical Physiology, The Scripps Research Institute, Center for Regenerative MedicineIt is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.https://doi.org/10.1038/ncomms10536
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring
spellingShingle	Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring Whole-genome mutational burden analysis of three pluripotency induction methods Nature Communications
author_facet	Kunal Bhutani Kristopher L. Nazor Roy Williams Ha Tran Heng Dai Željko Džakula Edward H. Cho Andy W. C. Pang Mahendra Rao Han Cao Nicholas J. Schork Jeanne F. Loring
author_sort	Kunal Bhutani
title	Whole-genome mutational burden analysis of three pluripotency induction methods
title_short	Whole-genome mutational burden analysis of three pluripotency induction methods
title_full	Whole-genome mutational burden analysis of three pluripotency induction methods
title_fullStr	Whole-genome mutational burden analysis of three pluripotency induction methods
title_full_unstemmed	Whole-genome mutational burden analysis of three pluripotency induction methods
title_sort	whole-genome mutational burden analysis of three pluripotency induction methods
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-02-01
description	It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.
url	https://doi.org/10.1038/ncomms10536
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Whole-genome mutational burden analysis of three pluripotency induction methods

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