Role of Water in the Selection of Stable Proteins at Ambient and Extreme Thermodynamic Conditions

Proteins that are functional at ambient conditions do not necessarily work at extreme conditions of temperature T and pressure P. Furthermore, there are limits of T and P above which no protein has a stable functional state. Here, we show that these limits and the selection mechanisms for working pr...

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Bibliographic Details
Main Authors: Valentino Bianco, Giancarlo Franzese, Christoph Dellago, Ivan Coluzza
Format: Article
Language:English
Published: American Physical Society 2017-06-01
Series:Physical Review X
Online Access:http://doi.org/10.1103/PhysRevX.7.021047