Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.

Increased B Cell ADAM10 in Allergic Patients and Th2 Prone Mice.

ADAM10, as the sheddase of the low affinity IgE receptor (CD23), promotes IgE production and thus is a unique target for attenuating allergic disease. Herein, we describe that B cell levels of ADAM10, specifically, are increased in allergic patients and Th2 prone WT mouse strains (Balb/c and A/J). W...

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Bibliographic Details
Main Authors: Lauren Folgosa Cooley, Rebecca K Martin, Hannah B Zellner, Anne-Marie Irani, Cora Uram-Tuculescu, Mohey Eldin El Shikh, Daniel H Conrad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4416757?pdf=render

Internet

http://europepmc.org/articles/PMC4416757?pdf=render

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