Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans

Abstract Background Epigenetic age acceleration, a measure of biological aging based on DNA methylation, is associated with cardiovascular mortality. However, little is known about its relationship with hypertensive target organ damage to the heart, kidneys, brain, and peripheral arteries. Methods W...

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Bibliographic Details
Main Authors: Jennifer A. Smith, Jeremy Raisky, Scott M. Ratliff, Jiaxuan Liu, Sharon L. R. Kardia, Stephen T. Turner, Thomas H. Mosley, Wei Zhao
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Medical Genomics
Subjects:
Epigenetic age
Age acceleration
DNA methylation
Target organ damage
Hypertension
Estimated glomerular filtration rate
Online Access:http://link.springer.com/article/10.1186/s12920-019-0585-5

Internet

http://link.springer.com/article/10.1186/s12920-019-0585-5

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