Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.

Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index.

Glucocorticoids (GCs) such as prednisolone are potent immunosuppressive drugs but suffer from severe adverse effects, including the induction of insulin resistance. Therefore, development of so-called Selective Glucocorticoid Receptor Modulators (SGRM) is highly desirable. Here we describe a non-ste...

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Bibliographic Details
Main Authors: Marie-José C van Lierop, Wynand Alkema, Anke J Laskewitz, Rein Dijkema, Hans M van der Maaden, Martin J Smit, Ralf Plate, Paolo G M Conti, Christan G J M Jans, C Marco Timmers, Constant A A van Boeckel, Scott J Lusher, Ross McGuire, Rene C van Schaik, Jacob de Vlieg, Ruben L Smeets, Claudia L Hofstra, Annemieke M H Boots, Marcel van Duin, Benno A Ingelse, Willem G E J Schoonen, Aldo Grefhorst, Theo H van Dijk, Folkert Kuipers, Wim H A Dokter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3495945?pdf=render

Internet

http://europepmc.org/articles/PMC3495945?pdf=render

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