HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0

Abstract Background Herpes simplex virus-1 (HSV-1) infections of the central nervous system (CNS) can result in HSV-1 encephalitis (HSE) which is characterized by severe brain damage and long-term disabilities. Different cell types including neurons and astrocytes become infected in the course of an...

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Bibliographic Details
Main Authors: Niko Hensel, Verena Raker, Benjamin Förthmann, Nora Tula Detering, Sabrina Kubinski, Anna Buch, Georgios Katzilieris-Petras, Julia Spanier, Viktoria Gudi, Sylvia Wagenknecht, Verena Kopfnagel, Thomas Andreas Werfel, Martin Stangel, Andreas Beineke, Ulrich Kalinke, Søren Riis Paludan, Beate Sodeik, Peter Claus
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
Neurotrophic factors
Fibroblast growth factors
FGF
ERK
Akt
Signaling
Online Access:https://doi.org/10.1186/s12974-019-1647-5

Internet

https://doi.org/10.1186/s12974-019-1647-5

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