Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity.

Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity.

Saccharomyces cerevisiae Rad9 is required for an effective DNA damage response throughout the cell cycle. Assembly of Rad9 on chromatin after DNA damage is promoted by histone modifications that create docking sites for Rad9 recruitment, allowing checkpoint activation. Rad53 phosphorylation is also...

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Bibliographic Details
Main Authors: Magda Granata, Federico Lazzaro, Daniele Novarina, Davide Panigada, Fabio Puddu, Carla Manuela Abreu, Ramesh Kumar, Muriel Grenon, Noel F Lowndes, Paolo Plevani, Marco Muzi-Falconi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2916856?pdf=render

Internet

http://europepmc.org/articles/PMC2916856?pdf=render

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