Indoxyl Sulfate—Review of Toxicity and Therapeutic Strategies

Indoxyl sulfate is an extensively studied uremic solute. It is a small molecule that is more than 90% bound to plasma proteins. Indoxyl sulfate is derived from the breakdown of tryptophan by colon microbes. The kidneys achieve high clearances of indoxyl sulfate by tubular secretion, a function not r...

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Bibliographic Details
Main Authors: Sheldon C. Leong, Tammy L. Sirich
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Toxins
Subjects:
Online Access:http://www.mdpi.com/2072-6651/8/12/358