Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

Ataxin-7 and Non-stop coordinate SCAR protein levels, subcellular localization, and actin cytoskeleton organization

Atxn7, a subunit of SAGA chromatin remodeling complex, is subject to polyglutamine expansion at the amino terminus, causing spinocerebellar ataxia type 7 (SCA7), a progressive retinal and neurodegenerative disease. Within SAGA, the Atxn7 amino terminus anchors Non-stop, a deubiquitinase, to the comp...

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Bibliographic Details
Main Authors: Veronica Cloud, Ada Thapa, Pedro Morales-Sosa, Tayla M Miller, Sara A Miller, Daniel Holsapple, Paige M Gerhart, Elaheh Momtahan, Jarrid L Jack, Edgardo Leiva, Sarah R Rapp, Lauren G Shelton, Richard A Pierce, Skylar Martin-Brown, Laurence Florens, Michael P Washburn, Ryan D Mohan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
Ataxin7
neurobiology
actin
WAVE regulatory complex
SAGA complex
Non-stop
Online Access:https://elifesciences.org/articles/49677

Internet

https://elifesciences.org/articles/49677

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