Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity

Calmangafodipir Reduces Sensory Alterations and Prevents Intraepidermal Nerve Fibers Loss in a Mouse Model of Oxaliplatin Induced Peripheral Neurotoxicity

Oxaliplatin (OHP) is an antineoplastic compound able to induce peripheral neurotoxicity. Oxidative stress has been suggested to be a key factor in the development of OHP-related peripheral neurotoxicity. Mangafodipir, a contrast agent possessing mitochondrial superoxide dismutase (MnSOD)-mimetic act...

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Bibliographic Details
Main Authors: Annalisa Canta, Alessia Chiorazzi, Eleonora Pozzi, Giulia Fumagalli, Laura Monza, Cristina Meregalli, Valentina A. Carozzi, Virginia Rodriguez-Menendez, Norberto Oggioni, Jacques Näsström, Paola Marmiroli, Guido Cavaletti
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antioxidants
Subjects:
calmangafodipir
oxaliplatin
IENF density
cold hyperalgesia
mechanical allodynia
neurotoxicity
Online Access:https://www.mdpi.com/2076-3921/9/7/594

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https://www.mdpi.com/2076-3921/9/7/594

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