A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

A novel brain tumour model in zebrafish reveals the role of YAP activation in MAPK- and PI3K-induced malignant growth

Somatic mutations activating MAPK and PI3K signalling play a pivotal role in both tumours and brain developmental disorders. We developed a zebrafish model of brain tumours based on somatic expression of oncogenes that activate MAPK and PI3K signalling in neural progenitor cells and found that HRASV...

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Bibliographic Details
Main Authors: Marie Mayrhofer, Victor Gourain, Markus Reischl, Pierre Affaticati, Arnim Jenett, Jean-Stephane Joly, Matteo Benelli, Francesca Demichelis, Pietro Luigi Poliani, Dirk Sieger, Marina Mione
Format: Article
Language:English
Published: The Company of Biologists 2017-01-01
Series:Disease Models & Mechanisms
Subjects:
Glioma
YAP
RAS
Zebrafish
Heterotopia
Online Access:http://dmm.biologists.org/content/10/1/15

Internet

http://dmm.biologists.org/content/10/1/15

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