Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways

Beyond Gap Junction Channel Function: the Expression of Cx43 Contributes to Aldosterone-Induced Mesangial Cell Proliferation via the ERK1/2 and PKC Pathways

Aims: This study aimed to explore the precise mechanism and signaling pathways of mesangial cell (MC) proliferation from a new point of view considering Connexin 43 (Cx43). Methods: MC proliferation was measured by the incorporation of 3H-thymidine (3H-TdR). Cx43 was over-expressed in MC cells using...

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Bibliographic Details
Main Authors: Aiqing Zhang, Ying Han, Bin Wang, Shanwen Li, Weihua Gan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Connexin 43
Gap junction
Mesangial cells
Proliferation
Online Access:http://www.karger.com/Article/FullText/430291

Internet

http://www.karger.com/Article/FullText/430291

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