Catalytic enantioselective construction of axial chirality in 1,3-disubstituted allenes

Highly enantioselective synthesis of allenes has been relying, so far, on the steric hindrance of substrates. Here the authors achieve excellent stereocontrol in the synthesis of chiral allenes with a palladium-DTBM-SEGPHOS catalytic system in a non-substrate-dependent manner.

Bibliographic Details
Main Authors: Shihua Song, Jing Zhou, Chunling Fu, Shengming Ma
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07908-1