The Influence of Long-Term Treatment with Asenapine on Liver Cytochrome P450 Expression and Activity in the Rat. The Involvement of Different Mechanisms

The Influence of Long-Term Treatment with Asenapine on Liver Cytochrome P450 Expression and Activity in the Rat. The Involvement of Different Mechanisms

Therapy of schizophrenia requires long-term treatment with a relevant antipsychotic drug to achieve a therapeutic effect. The aim of the present study was to investigate the influence of prolonged treatment with the atypical neuroleptic asenapine on the expression and activity of rat cytochrome P450...

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Bibliographic Details
Main Authors: Przemysław J. Danek, Ewa Bromek, Władysława A. Daniel
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
asenapine
chronic treatment
rat liver
cytochrome P450 expression
enzyme activity
Online Access:https://www.mdpi.com/1424-8247/14/7/629

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https://www.mdpi.com/1424-8247/14/7/629

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