Analysis of Hierarchical Organization in Gene Expression Networks Reveals Underlying Principles of Collective Tumor Cell Dissemination and Metastatic Aggressiveness of Inflammatory Breast Cancer

Analysis of Hierarchical Organization in Gene Expression Networks Reveals Underlying Principles of Collective Tumor Cell Dissemination and Metastatic Aggressiveness of Inflammatory Breast Cancer

Clusters of circulating tumor cells (CTCs), despite being rare, may account for more than 90% of metastases. Cells in these clusters do not undergo a complete epithelial-to-mesenchymal transition (EMT), but retain some epithelial traits as compared to individually disseminating tumor cells. Determin...

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Bibliographic Details
Main Authors: Shubham Tripathi, Mohit Kumar Jolly, Wendy A. Woodward, Herbert Levine, Michael W. Deem
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
collective dissemination
inflammatory breast cancer
epithelial-to-mesenchymal transition
hierarchy
hybrid E/M
cophenetic correlation coefficient
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00244/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00244/full

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