Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Quantitative in vivo whole genome motility screen reveals novel therapeutic targets to block cancer metastasis

Tumour metastasis is dependent on tumour cell motility. Here, the authors investigate genes required for tumour cell motility by establishing a quantitative in vivo screening platform based on intravital imaging of human cancer metastasis in ex ovo avian embryos.

Bibliographic Details
Main Authors: Konstantin Stoletov, Lian Willetts, Robert J. Paproski, David J. Bond, Srijan Raha, Juan Jovel, Benjamin Adam, Amy E. Robertson, Francis Wong, Emma Woolner, Deborah L. Sosnowski, Tarek A. Bismar, Gane Ka-Shu Wong, Andries Zijlstra, John D. Lewis
Format: Article
Language:English
Published: Nature Publishing Group 2018-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04743-2

Internet

https://doi.org/10.1038/s41467-018-04743-2

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