Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response

Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response

Thrombin, the ligand of the protease-activated receptor 1 (PAR1), is a well-known stimulator of proangiogenic responses in vascular endothelial cells (ECs), which are mediated through the induction of vascular endothelial growth factor (VEGF). However, the transcriptional events underlying this thro...

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Bibliographic Details
Main Authors: Rusan Catar, Guido Moll, Isa Hosp, Michele Simon, Christian Luecht, Hongfan Zhao, Dashan Wu, Lei Chen, Julian Kamhieh-Milz, Katarzyna Korybalska, Daniel Zickler, Janusz Witowski
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
cardiovascular diseases (CVD)
endothelial cells (ECs)
innate immune response
thromboinflammation
thrombin
protease-activated receptor 1 (PAR-1)
Online Access:https://www.mdpi.com/2073-4409/10/4/910

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https://www.mdpi.com/2073-4409/10/4/910

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