Brain MRI Reveals Ascending Atrophy in Parkinson's Disease Across Severity

Models which assess the progression of Lewy pathology in Parkinson's disease have proposed ascending spread in a caudal-rostral pattern. In-vivo human evidence for this theory is limited, in part because there are no biomarkers that allow for direct assessment of Lewy pathology. Here, we measur...

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Bibliographic Details
Main Authors: Jamie C. Blair, Matthew J. Barrett, James Patrie, Joseph L. Flanigan, Scott A. Sperling, W. Jeffrey Elias, T. Jason Druzgal
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Neurology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.01329/full