Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum

Role of LrrkA in the Control of Phagocytosis and Cell Motility in Dictyostelium discoideum

LrrkA is a Dictyostelium discoideum kinase with leucine-rich repeats. LrrkA stimulates Kil2 and intra-phagosomal killing of ingested bacteria in response to folate. In this study, we show that genetic inactivation of lrrkA also causes a previously unnoticed phenotype: lrrkA KO cells exhibit enhanced...

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Bibliographic Details
Main Authors: Romain Bodinier, Ayman Sabra, Jade Leiba, Anna Marchetti, Otmane Lamrabet, Imen Ayadi, Vedrana Filić, Takefumi Kawata, Igor Weber, Pierre Cosson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
LrrkA
folate
phagocytosis
motility
Dictyostelium discoideum
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.629200/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.629200/full

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