Pharmacokinetic-Pharmacodynamic Correlation for Meropenem Applied to a Burn Child Using a Bioanalytical Liquid Cromatographic Method

Pharmacokinetic-Pharmacodynamic Correlation for Meropenem Applied to a Burn Child Using a Bioanalytical Liquid Cromatographic Method

Bioanalytical method for LC meropenem quantification in plasma was described. Good absolute recovery (higher than 90%), adequate linearity (0.2-50.0 μg/mL, r2=0.999), high sensitivity (LOQ: 0.2 μg/mL; LOD: 0.1μg/mL) and acceptable stability were shown. Interday/intraday precisions were 2.3%/2.0% and...

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Bibliographic Details
Main Authors: Silvia R. C. J. Santos, Cristina Sanches-Giraud, Carlindo Vieira Jr., Flávio F. de Souza, David S. Gómez, Edvaldo V. Campos, Rodrigo P. de Azevedo, Marcus C. Ferreira, Jorge W. L. Nascimento
Format: Article
Language:English
Published: Formifarma, LDA. 2011-10-01
Series:Revista Portuguesa de Farmacoterapia
Subjects:
Meropenem
LC
burn child
drug plasma monitoring
pharmacokinetics-pharmacodinamics correlation
Online Access:http://revista.farmacoterapia.pt/index.php/rpf/article/view/79

Internet

http://revista.farmacoterapia.pt/index.php/rpf/article/view/79

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